"Sildenafil (Viagra), a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction". "Drug repositioning: identifying and developing new uses for existing drugs". Archived from the original on 22 April 2019. Archived from the original on 10 June 2019.
- Sildenafil citrate 120 mg can cause prolonged erections if misused.
- This dose may increase the risk of cardiovascular side effects.
- Always consult a healthcare provider before taking high doses of sildenafil.
- Combining sildenafil with nitrates can cause dangerous blood pressure drops.
- Side effects may include flushing, nasal congestion, and dizziness.
- Sildenafil is metabolized in the liver and excreted via feces and urine.
"Health situation in former communist bloc is dire, says Unicef". Archived from the original on 1 November 2012. ^ Gurevich M, Cormier N, Leedham U, Brown-Bowers A (August 2018). Sexuopharmaceutical use by men as prevention and proficiency". "Spreading the Word, but What Word is That? Viagra and Male Sexuality in Popular Culture". "A new view of women's sexual problems: Why new? Archived from the original on 3 January 2009.
- Patients with liver or kidney issues need dose adjustments and careful monitoring.
- The recommended maximum dose for sildenafil is generally 100 mg per day.
- Excessive use increases the likelihood of adverse cardiovascular events.
- Use of sildenafil does not provide protection against sexually transmitted infections.
- Some users report a persistent blue-tinged vision after high doses.
- It’s essential to obtain sildenafil from reputable sources to avoid counterfeit products.
Archived from the original on 12 October 2008. "Sales of Impotence Drugs Fall, Defying Expectations". Archived from the original on 11 October 2007. ^ "Pfizer Courting More Controversy with Viagra 'Advergaming'".
How should I take sildenafil?
^ "Hidden Risks of Erectile Dysfunction 'Treatments' Sold Online". Archived from the original on 23 April 2019. ^ R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 9th edition, Biomedical Publications, Seal Beach, CA, 2011, pp. Archived from the original (PDF) on 10 September 2011.
1. State-of-the-Art Manufacturing Infrastructure
"Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules". ^ a b Webb DJ, Freestone S, Allen MJ, Muirhead GJ (March 1999). "Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist". ^ Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA (May 1998). "Oral sildenafil in the treatment of erectile dysfunction. Archived from the original on 19 December 2019. Archived from the original on 6 May 2018. Archived from the original on 9 January 2009. Archived from the original on 22 February 2021. ^ a b "Viagra now available over the counter without prescription in the UK". Archived from the original on 26 March 2021. Archived from the original on 8 December 2013. "The coming generics threat to Pfizer's Viagra brand just got scarier". Archived from the original on 9 September 2017.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Soft Tabs | 100mg | 84 + 4 Pills | 233.05€ 221.95€ | |
| Kamagra Oral Jelly | 100mg | 21 Sachets | 95.92€ 91.35€ | |
| Viagra Generic | 100mg | 30 + 4 Pills | 60.91€ 58.01€ | |
| Kamagra Soft Tabs | 100mg | 272 + 12 Pills | 593.42€ 565.16€ | |
| Kamagra Soft Tabs | 100mg | 180 + 8 Pills | 425.45€ 405.19€ | |
| Viagra Generic | 50mg | 90 + 6 Pills | 107.37€ 102.26€ | |
| Viagra Generic | 200mg | 30 + 2 Pills | 83.07€ 79.11€ | |
| Kamagra Oral Jelly | 100mg | 90 + 8 Sachets | 303.56€ 289.10€ | |
| Kamagra Oral Jelly | 100mg | 30 + 5 Sachets | 136.20€ 129.71€ | |
| Viagra Generic | 150mg | 360 + 10 Pills | 423.48€ 403.31€ | |
| Viagra Generic | 150mg | 120 + 8 Pills | 177.58€ 169.12€ | |
| Kamagra Oral Jelly | 100mg | 63 + 7 Sachets | 224.18€ 213.50€ |
^ "Viagra to go generic in 2017 according to sildenafil premature ejaculation Pfizer agreement". Archived from the original on 1 December 2017. "Sex, Drugs and That Little Blue Pill". Archived from the original on 6 December 2017. "Why Pfizer Is About to Slash Viagra's Price in Half". Archived from the original on 7 December 2017. "Pfizer to lose patent of drug Viagra, Indian companies gear up with copycat versions: Pfizer's patent for the formulation of Viagra, used to treat impotence in men, ends in the US in 2020". Archived from the original on 17 April 2021. ^ "Set to conquer US, Indian 'Viagras' may give Pfizer a hard Time". Archived from the original on 22 December 2020. ^ a b "Pfizer Settles Viagra® Patent Litigation With Teva". "Lockout Supplements Issues Voluntary Nationwide Recall of Boner Bears Chocolate Syrup Due to Undeclared Sildenafil". Archived from the original on 19 November 2016.
5.6 Adverse Reactions with the Concomitant Use of Ritonavir
Archived from the original on 14 January 2012. "Onset and duration of action of sildenafil for the treatment of erectile dysfunction". ^ "Scientist who developed Viagra receives knighthood in New Year's Honours". Archived from the original on 14 January 2023. "Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond".
What dose should be taken?
Archived from the original on 26 September 2008. Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments. Morriston Hospital in Swansea, was the first in the world to trial Viagra! ^ Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, et al. "Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction". "Counterfeit Viagra, Cialis, Levitra: The Ultimate Guide". Archived from the original on 10 January 2017. "Online pharmacies suspected of counterfeit drug sales".
| Country | Approval Status | Maximum Allowed Dose | Remarks |
|---|---|---|---|
| United States | Approved for ED and pulmonary hypertension | 120 mg | Prescription-only, controlled use |
| European Union | Approved for ED, off-label for other uses | 120 mg | Stringent prescribing regulations |
| Canada | Approved, similar to US | 120 mg | Must be prescribed by healthcare provider |
| Australia | Approved with restrictions | 120 mg | Medical supervision required |
| India | Available, OTC in some regions | 120 mg | Use under medical guidance recommended |
^ "Erectile Dysfunction Medication the Most Seized Drug During Global Crackdown, Interpol Says".
- Overuse of sildenafil 120 mg may result in severe headache and nausea.
- Alcohol can reduce sildenafil effectiveness and worsen side effects.
- Always follow the doctor’s instructions for dosing and timing.
- Sildenafil should be stored away from moisture, heat, and light.
- Do not mix sildenafil with recreational drugs like 'poppers' or stimulants.
- Sudden vision loss is rare but requires immediate medical attention.
^ "Global illicit medicines targeted by INTERPOL operation". Archived from the original on 10 December 2023. ^ "Israeli-made AI exposes international fake Viagra network". ^ "Counterfeit Viagra Pills, Footwear, Belts, Car Emblems and Headphones Worth over $32 Million Seized at the LA/Long Beach Seaport U.S. Customs and Border Protection". Archived from the original on 12 chew sildenafil October 2013. "Yes, There Is a Way to Get Generic Viagra". Archived from the original on 2 May 2016. "Pfizer Wins Viagra Patent Infringement Case Against Teva Pharmaceuticals". Archived from the original on 11 January 2015. ^ "Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan". Retrieved 17 June 2024 – via Business Wire. Archived from the original on 17 June 2024. "Viagra patent expires in June, says Brazilian court". Archived from the original on 17 April 2012. ^ "Revatio patent ruled invalid for lack of sound prediction and obviousness". Archived from the original on 3 March 2016. {{cite web}}: CS1 maint: deprecated archival service (link) ^ Teva Canada Ltd. v. Pfizer Canada Inc., 2012 SCC 60 at par. "Supreme Court ruling could lead to cheaper versions of Viagra". Archived from the original on 10 March 2013. "Canadian Supreme court rules Viagra patent invalid". Archived from the original on 11 November 2012. ^ "Viagra patent tossed out by Supreme Court: Decision allows generic versions of drug to be produced".
5.7 Combination with other PDE5 Inhibitors or Other Erectile Dysfunction Therapies
"Source: Roger Clemens, host of athletes pop Viagra to help onfield performance". Archived from the original on 14 August 2020. "Bears' Brandon Marshall says some NFL players use Viagra .. on the Field". Archived from the original on 5 March 2016.
How should I store sildenafil?
"Towards a decade of detecting new analogues of sildenafil, tadalafil and vardenafil in food supplements: a history, analytical aspects and health risks". "Detection of sildenafil analogues in herbal products for erectile dysfunction". Archived from the original on 4 March 2016. ^ "FDA Warns Consumers About Dangerous Ingredients in "Dietary Supplements" Promoted for Sexual Enhancement". Archived from the original on 18 January 2017. Archived from the original on 18 September 2013. ^ "Pfizer Canada drops Viagra price after generic versions get Supreme Court green light". Archived from the original on 30 November 2012. Archived from the original on 27 December 2013. "In rare move, Pfizer asks Supreme Court to reconsider ruling that killed Viagra patent". Archived from the original on 5 February 2013. "The Supreme Court of Canada holds Pfizer's Viagra patent invalid". Archived from the original on 20 May 2013. ^ "Actavis Launches Generic Viagra in Europe as Patents Expire". Archived from the original on 29 October 2013. "What Will Happen When Viagra Goes Generic?". Archived from the original on 23 April 2011. ^ "Is Viagra about to lose its pulling power in the UK?". Archived from the original on 30 October 2013. Archived from the original on 22 August 2009. Archived from the original on 25 June 2007. "Viagra from the pharmacist: insight from reclassification in New Zealand". Archived from the original on 17 May 2021. ^ "Generic Viagra developers queue up, but may have to wait".
| Property | Description | Typical Dose | Onset of Action | Duration of Effect | Mechanism of Action |
|---|---|---|---|---|---|
| Bioavailability | Approximately 40% | 120 mg | 30-60 minutes | Up to 6 hours | Inhibits PDE5 enzyme in smooth muscle |
| Half-life | Approximately 4 hours | N/A | N/A | N/A | Enhances nitric oxide signaling |
| Metabolism | Liver via CYP3A4 and CYP2C9 | N/A | N/A | N/A | Prevents cGMP breakdown |
| Excretion | Mainly via feces (80%), urine (13%) | N/A | N/A | N/A | Eliminates unchanged drug |
| Peak Plasma Levels | Achieved within 30-120 minutes | 120 mg | 30 minutes | N/A | Related to dose and absorption rate |
Archived from the original on 28 December 2021. ^ "Approved Viagra copies flood drugstores in Korea". ^ "Viagra prescriptions almost triple in a decade". Archived from the original on 1 July 2024. ^ "MHRA reclassifies Viagra Connect tablets to a Pharmacy medicine". ^ "Viagra to be available without prescription in UK". We are a leading of 120mg cobra sildenafil citrate tablet, 120 mg vega extra cobra sildenafil citrate tablets and 120mg de cobra sidenafil tablets from Mumbai, India. Sildenafil Tablet is a prescription medicine used to treat erectile dysfunction (impotence) in men.
Usual Geriatric Dose for Erectile Dysfunction
Archived from the original on 4 September 2014. "Recreational use and misuse of phosphodiesterase 5 inhibitors". Archived from the original on 21 August 2016. "Sildenafil does not improve sexual function in men without erectile dysfunction but does reduce the postorgasmic refractory time". ^ McCambridge J, Mitcheson L, Hunt N, Winstock A (March 2006).
Altitude sickness
"The rise of Viagra among British illicit drug users: 5-year survey data". "Does marijuana use play a role in the recreational use of sildenafil?". Archived from the original on 26 January 2013. "Sildenafil accelerates reentrainment of circadian rhythms after advancing light schedules". Proceedings of the National Academy of Sciences of the United States of America. It works by increasing blood flow to the penis. This helps men to get or maintain an erection. It belongs to a group of medicines known as phosphodiesterase type 5 (PDE 5) inhibitors.Sildenafil Tablet may be taken on an empty stomach or with a meal. It should be strictly taken as advised by your doctor. You should take it about 1 hour before you plan to have sex.
| Common Side Effects | Frequency | Serious Side Effects | Warning Signs | Management Tips |
|---|---|---|---|---|
| Headache | Common | Sudden vision loss | Vision changes, eye pain | Seek medical attention immediately |
| Flushing | Common | Priapism (painful erection) | Erections lasting >4 hours | Seek emergency care |
| Nasal Congestion | Common | Hypotension | Dizziness, fainting | Sit or lie down, hydrate |
| Indigestion (Dyspepsia) | Occasional | Hearing loss | Sudden deafness or ringing | Discontinue use and consult doctor |
| Muscle Pain | Less common | Severe allergic reactions | Rash, difficulty breathing | Discontinue and seek help |
The amount of time it takes to work varies from person to person, but it normally takes between 30 minutes and 1 hour. This medicine will only help you to get an erection if you are sexually stimulated. However, you should not take this medicine if you do not have erectile dysfunction. It should not be taken more than once a day.This medicine is not intended for use by women and men should avoid using any other medicines to treat impotence without talking to a doctor first. It can be dangerous to take it along with medicines called nitrates (often given for chest pain or angina). Do not take this medicine if you have severe heart or liver problems, have recently had a stroke or heart attack or if you have low blood pressure. Let your doctor know if you suffer from these or any other health problems before taking it. You should not drive if this medicine makes you feel dizzy. Avoid drinking alcohol while taking this medicine as it increases the chances of side effects. Sildenafil Tablet may be taken on an empty stomach or with a meal. It should not be taken more than once a day.
- Sildenafil 120 mg is not approved by all regulatory agencies for general use.
- The maximum recommended dose for most individuals is 100 mg.
- Using high doses can lead to increased cardiovascular strain.
- Always inform your doctor of all medications to prevent interactions.
- Sildenafil may cause a sudden drop in blood pressure, especially with certain drugs.
- The medication can be used as part of a treatment plan for erectile dysfunction.