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If you have chest pain during sexual activity, call your doctor immediately and avoid sexual activity until your doctor tells you otherwise. Tell all your healthcare providers that you are taking vardenafil. If you ever need emergency medical treatment for a heart problem, the healthcare providers who treat you will need to know when you last took vardenafil. If you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent damage to your brain that can cause severe intellectual disability), you should know that the rapidly disintegrating tablets are sweetened with aspartame, a source of phenylalanine.
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Check your medication’s bottle for a specific date and always dispose of expired medication.15 Check your medication’s bottle for a specific date and always dispose of expired medication.15 Before taking vardenafil: Tell your doctor and pharmacist if you are allergic to vardenafil, any other medications or any of the ingredients in vardenafil tablets. Ask your pharmacist for a list of the ingredients. Do not take vardenafil if you are taking or have recently taken riociguat (Adempas) or nitrates such as isosorbide dinitrate (dilatrate-SR, Isordil, in BiDil), isosorbide mononitrate (Monoket) or nitroglycerin (Minitran, Nitro-Dur, NitroMist, Nitrostat, others). Nitrates come as tablets, sublingual (under the tongue) tablets, sprays, patches, pastes and ointments. Ask your doctor if you are not sure if any of your medications contain nitrates. If you have fructose intolerance (an inherited condition in which the body lacks the protein needed to break down fructose) you should know that the rapidly disintegrating tablets are sweetened with the fruit sugar sorbitol.
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John's wort. Tell your doctor if you smoke and if you have ever had an erection that lasted more than four hours. Also tell your doctor if you have or have ever had a condition that affects the shape of the penis, such as angulation, cavernosal fibrosis or Peyronie's disease; diabetes; high cholesterol; high or low blood pressure; irregular heartbeat; a heart attack; angina (chest pain); a stroke; ulcers in the stomach or intestine; a bleeding disorder; blood cell problems such as sickle cell anemia (a disease of the red blood cells), multiple myeloma (cancer of the plasma cells) or leukemia (cancer of the white blood cells); seizures; or liver, kidney or heart disease. Also tell your doctor if you or any of your family members have or have ever had long QT syndrome (a heart condition) or retinitis pigmentosa (an eye disease), or if you have ever had severe vision loss, especially if you were told the vision loss was caused by a blockage of blood flow to the nerves that help you see. Tell your doctor if you have ever been advised by a healthcare professional to avoid sexual activity for medical reasons. Tell your doctor if you have fructose intolerance.16 Tell your doctor and pharmacist if you are allergic to vardenafil, any other medications or any of the ingredients in vardenafil tablets. Tell your doctor and pharmacist if you are allergic to vardenafil, any other medications or any of the ingredients in vardenafil tablets. Tell your doctor if you have fructose intolerance.16 If you have fructose intolerance (an inherited condition in which the body lacks the protein needed to break down fructose) you should know that the rapidly disintegrating tablets are sweetened with the fruit sugar sorbitol. Tell your doctor if you have fructose intolerance.16 Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.
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Vardenafil is not FDA approved for women. It may be prescribed in certain situations, but more research is needed to determine the medication’s full effect.13 Vardenafil is not FDA approved for women. It may be prescribed in certain situations, but more research is needed to determine the medication’s full effect.13 PDE5 inhibitors such as sildenafil, tadalafil, avanafil and vardenafil all work in the same basic way by relaxing blood vessels to increase blood flow to the penis. They are all effective for treating erectile dysfunction, but they differ mainly in how quickly they start working and how long their effects last.14Read our Complete Guide to Compare ED Medications to learn more. PDE5 inhibitors such as sildenafil, tadalafil, avanafil and vardenafil all work in the same basic way by relaxing blood vessels to increase blood flow to the penis. Grapefruit can raise the levels of vardenafil in your body and increase the risk of side effects.17 Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine. Grapefruit can raise the levels of vardenafil in your body and increase the risk of side effects.17 Tell your doctor if any of these symptoms are severe or do not go away: Headache Upset stomach Heartburn Flushing Stuffy or runny nose Flu-like symptoms Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately: An erection lasting longer than four hours Sudden severe loss of vision (see below for more information) Blurred vision Changes in color vision such as seeing blue tinge on objects, difficulty telling the difference between blue and green, or difficulty seeing at night Dizziness Sudden decrease or loss of hearing Ringing in ears Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles or lower legs Hoarseness Difficulty breathing or swallowing Fainting Hives or rash Vardenafil may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. Some patients experienced a sudden loss of some or all their vision after they took vardenafil or other medications that are similar to vardenafil.
Other Effects
If you are taking the rapidly disintegrating tablets, your doctor will not be able to adjust your dose because the rapidly disintegrating tablets are only available in one strength. If you need a higher or lower dose, your doctor may prescribe regular tablets instead. Tell your doctor if vardenafil is not working well or if you are experiencing side effects. Vardenafil rapidly disintegrating tablets cannot be substituted for vardenafil tablets. Be sure you receive only the type of vardenafil that was prescribed by your doctor. The vision loss was permanent in some cases. It is not known if the vision loss was caused by the medication. If you experience a sudden loss of vision while you are taking vardenafil, call your doctor immediately.
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Do not take street drugs containing nitrates such as amyl nitrate or butyl nitrate (poppers) while taking vardenafil. Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins and nutritional supplements you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may interact with vardenafil, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Tell your doctor what herbal products you are taking, especially St. Do not take any more doses of vardenafil or similar medications such as sildenafil (Viagra) or tadalafil (Cialis) until you talk to your doctor. Some patients experienced a sudden decrease or loss of hearing after they took vardenafil or other medications that are similar to vardenafil. The hearing loss usually involved only one ear and may not get better. It is not known if the hearing loss was caused by the medication.
Drug interactions
Ask your pharmacist if you have any questions about the type of vardenafil you were given.11 Vardenafil comes as a tablet and a rapidly disintegrating (dissolves in the mouth and is swallowed without water) tablet to take by mouth. Ask your pharmacist if you have any questions about the type of vardenafil you were given.11 Vardenafil is prescribed in 5 mg, 10 mg and 20 mg doses, meant to be taken once a day, as needed.12 Vardenafil is prescribed in 5 mg, 10 mg and 20 mg doses, meant to be taken once a day, as needed.12 A prescription for vardenafil is as low as $3 per tablet without insurance if you use RedBox Rx. A prescription for vardenafil is as low as $3 per tablet without insurance if you use RedBox Rx. Vardenafil is not available over the counter and requires a prescription. You can get vardenafil online, if prescribed, from RedBox Rx. If you experience a sudden loss of hearing, sometimes with ringing in the ears or dizziness, while you are taking vardenafil, call your doctor immediately.
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You should know that vardenafil is only for use in males. Women should not take vardenafil, especially if they are or could become pregnant, or are breastfeeding. If a pregnant woman takes vardenafil, she should call her doctor. If you are having surgery, including dental surgery or any dental procedure, tell the doctor or dentist that you are taking vardenafil. You should know that sexual activity may be a strain on your heart, especially if you have heart disease. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).18 Tell your doctor if any of these symptoms are severe or do not go away: If you experience any of the following symptoms, call your doctor immediately: An erection lasting longer than four hours An erection lasting longer than four hours Sudden severe loss of vision (see below for more information) Sudden severe loss of vision (see below for more information) Changes in color vision such as seeing blue tinge on objects, difficulty telling the difference between blue and green, or difficulty seeing at night Changes in color vision such as seeing blue tinge on objects, difficulty telling the difference between blue and green, or difficulty seeing at night Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles or lower legs Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles or lower legs Call your doctor if you have any unusual problems while taking this medication.